"The functional plasticity of macrophages allows an adaptative response to environmental signals."
WE DEVELOP MODULATORS OF MACROPHAGES’ POLARIZATION
The identification of rational approaches based on molecular understanding of Radio-Onco-Immunology should help to better select new combinatorial therapeutic strategies to fight against cancer.
Understanding « tumor-host » interactions is crucial for the development of novel immuno-oncology therapeutic approaches:
Tumor-associated macrophages (TAMs) are key components of the cancer microenvironment.
The functional plasticity of macrophages allows an adaptive response to environmental signals.
TAMs infiltration is associated with treatment resistance and poor clinical outcomes in the majority of cancers.
Therefore reprogramming of TAMs from anti-inflammatory to the pro-inflammatory phenotype is proposed to improve effectiveness of conventional anti-cancer treatments and immunotherapies.
Distinct transcriptional programs can be induced to shape macrophage functional phenotypes.
Findimmune researchers have characterized a novel macrophage immune checkpoint and signalling pathway that dictates pro-inflammatory and anti-inflammatory phenotypes of macrophages.
Findimmune initiated drug screenings to identify modulators of this novel immune checkpoint and select candidates for macrophage reprogramming to favor:
A pro-inflammatory phenotype in the context of cancer treatment
An anti-inflammatory phenotype for the treatment of immune-related diseases, with one candidate F2001 to fight cytokine storm of acute respiratory distress syndrome.